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Intact Genomics Awarded NIH SBIR Phase II Grant to Develop Novel Technology for New Natural Product Discovery

Intact Genomics, Inc. announced that it has received a Small Business Innovation Research (SBIR) Phase II grant totaling approximately $1.5 M from the National Center for Complementary & Integrative Health of the National Institute of Health. Under the 2-year grant, Intact Genomics will collaborate with two groups led by Nancy Keller and Jinwoo Bok, Professors of Mycology at University of Wisconsin – Madison, and Neil L. Kelleher,Professor of Chemistry at Northwestern University, to develop a robust heterologous expression system of intact fungal secondary metabolite gene clusters for natural product discovery in Aspergillus nidulans.

Please see the Link below for more information:
https://www.stltoday.com/pr/business/intact-genomics-awarded-nih-sbir-phase-ii-grant-to-develop/article_d65c1a7a-6502-11e8-ac23-5cb9017beffc.html

Intact Genomics Hosts “Spark! Bioscience” at the Helix Center

On March 02, 2018, Intact Genomics hosted students from Parkway’s “Spark! Bioscience.” “Spark! Bioscience” provides groundbreaking education to high school juniors and seniors through experiencing the world of science at the college and professional level. Andrew Robertson, Sales Manager of Intact Genomics, presented the history and innovative aspects of Intact Genomics, the Helix Center and the 39 North AgTech Innovation District.

Intact Genomics Attended and Presented at PAG XXVI Conference in San Diego

Dr. Charles Wu (Founder/CEO) and Andy Robertson (Sales Manager) of Intact Genomics attended The Plant and Animal Genome XXVI Conference (PAG) on January 13 through 17, 2018 in San Diego, CA, USA. Andy discussed our molecular biology tools and innovative technologies at the Intact Genomics booth during the exhibition and Dr. Wu presented our technologies at two workshops:

Fungal Genomics– Sunday, January 14, 2018- 04:25 PM–
“A Scalable Platform to Identify Fungal Secondary Metabolites and their Gene Clusters”

Synthetic Biology– Tuesday, January 16, 2018- 10:30 AM–
“A Versatile Semi-Synthetic Tool-Fungal Artificial Chromosome (FAC)”

The 2017 BIO Investor Forum selected Intact Genomics as one Nominee in the Buzz of BIO Contest.

Intact Genomics was selected as one Nominee of the Diagnostics & Beyond category in the Buzz of BIO Contest, recognizing the most innovative companies at the 2017 BIO Investor Forum. For more information, please go to: http://bit.ly/IamTheBuzz.

BIO (Biotechnology Innovation Organization) is the world’s largest biotechnology trade association representing biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 other nations. The BIO Investor Forum is an international biotech investor conference focused on early and established private companies as well as emerging public companies. The 2017 BIO Investor Forum was hosted in San Francisco, California in October 17-18.

Nature Chemical Biology published NIH SBIR supported research by scientists from Intact Genomics, UW-Madison and Northwestern University.

The August issue of Nature Chemical Biology (August 2017, Vol 13, No 8) published NIH SBIR supported research – “A scalable platform to identify fungal secondary metabolites and their gene clusters” by scientists from Intact Genomics, UW-Madison and Northwestern University. The cover page of that issue was an illustration of the Fungal Artificial Chromosomes (FAC) platform, which highlights the novelty and significance of FAC technology for the discovery of fungal natural products and potential drugs leads. For more details, click http://www.nature.com/nchembio/journal/v13/n8/covers/index.html.

The cover depicts conidiophores of the fungus Aspergillus nidulans carrying a fungal artificial chromosome (FAC), imaged by a scanning electron microscope and colored artificially. Filamentous fungi are prolific producers of secondary metabolites, and the combination of FAC technology with metabolomic scoring enables the high-throughput linkage of these metabolites with their biosynthetic gene clusters.

Intact Genomics Partners with Geneva Biotech

Intact has partnered with Geneva Biotech to offer North American customers competent cells containing Geneva Biotech’s viral genomes. Geneva Biotech is a privately held biotechnology company based in Geneva, Switzerland. Geneva Biotech develops a world class portfolio of viral and nonviral gene delivery systems and to market them across a broad spectrum of application fields, for more information about Geneva Biotech, click: http://geneva-biotech.com. Intact Genomics is proud to partner with Geneva Biotech to manufacture and distribute MultiBac™ and MultiBacMam™ Cell Lines and Kits.

Scientists from Intact Genomics, University of Wisconsin – Madison and Northwestern University, Partnered to Build New Platform for the Discovery of New Drug Leads from the Microbial World

St. Louis – (June 12, 2017) Today scientists from St. Louis-based Intact Genomics, a world leader of research and services around large DNA fragment cloning and metagenomics related technologies; the University of Wisconsin – Madison; and Northwestern University, announced that their research to develop a new, scalable platform that harvests valuable lead compounds from fungi, using a technology known as Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS) was published by the Nature Chemical Biology. For the article please click here.

The FAC-MS approach harnesses fungi to create powerful molecules honed through evolution by capturing large swaths of their DNA in a special system for robust production and identification of new molecules. Most notable, the company has also developed another disruptive technology of soil shuttle BAC-NGS (next generation sequencing) to capture 100-kb large DNA directly from soil and environmental uncultivable microbes for large-scale natural product discovery. The new 100-kb large DNA platforms will transform the process of discovering new bioactive molecules for application to numerous human diseases through the systematic discovery of new drug leads from the microbial world. For more information, please click here.

There are more press releases: “Fungal Genomic Breakthrough Unlocks a ‘Gold Rush’ of New Drug Discoveries” from Discovery Channel Seeker; “Intact Genomics, Collaborators Develop Workflow for Natural Products Discovery” from Genomeweb; and “Technology unlocks mold genomes for new drugs” from Phys.org.

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